Multisystem inflammatory syndrome in children related to COVID-19: a systematic review

Conclusion: PIMS-TS/MIS(-C) is a severe, heterogeneous disease with epidemiological enrichment for males, adolescents, and racial and ethnic minorities. However, mortality rate is low and short-term outcome favorable. Long-term follow-up of chronic complications and additional clinical research to elucidate the underlying pathogenesis is crucial.What is Known:• A novel pediatric inflammatory syndrome with multisystem involvement has been described in association with SARS-CoV-2.• To date, the scattered reporting of cases and use of different case definitions provides insufficient insight in the full clinical spectrum, epidemiological and immunological features, and prognosis.What is New:• This systematic review illustrates the heterogeneous spectrum of PIMS-TS/MIS(-C) and its epidemiological enrichment for males, adolescents, and racial and ethnic minorities.• Despite its severe presentation, overall short-term outcome is good.• The WHO MIS definition is preferred, as it is more precise, while encompassing most cases.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research