Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer

Autophagy and cell-cycle checkpoints act in concert to confer cellular radioresistance. We investigated the functional interaction between radiation-induced autophagy and G2 checkpoint activation in highly radioresistant human pancreatic ductal adenocarcinoma (PDAC) cells.

Source: International Journal of Radiation Oncology * Biology * Physics - June 7, 2021 Category: Radiology Authors: Motofumi Suzuki, Mayuka Anko, Maki Ohara, Ken-ichiro Matsumoto, Sumitaka Hasegawa Tags: Biology Contribution Source Type: research