Modulation of miR-382-5p reduces apoptosis of myocardial cells after acute myocardial infarction

CONCLUSION: To summarise, our study showed an increase in miR-382-5p in myocardial tissues in the AMI mouse model. Interference with miR-382-5p reduced apoptosis of myocardial cells after AMI and the effect was achieved by increasing STC1 expression.PMID:34042547 | DOI:10.1080/08916934.2021.1910812
Source: Autoimmunity - Category: Allergy & Immunology Authors: Source Type: research

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Authors: Sabet Sarvestani F, Azarpira N Abstract Heart and cerebral infarctions, as two important ischemic diseases, lead to the death of tissues due to inadequate blood supply and high mortality worldwide. These statuses are started via blockage of vessels and depletion of oxygen and nutrients which affected these areas. After reperfusion and restoration of oxygen supply, more severe injury was mediated by multifaceted cascades of inflammation and oxidative stress. microRNAs (miRNAs) as the regulator of biological and pathological pathways can adjust these conditions by interaction with their targets. Also, miRNAs...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
AbstractThe role of drug-coated balloons (DCBs) in patients with acute myocardial infarction (AMI) remains controversial. We performed a meta-analysis of all published studies comparing the outcomes of DCBs vs. stenting in AMI patients. Four studies with 497 patients (534 lesions) were included (three randomized controlled trials and one observational study). During a mean follow-up of 9  months (range 6–12 months), DCBs were associated with similar risk of major adverse cardiovascular events (5% vs. 4.4%; OR 1.24, 95% CI: [0.34, 4.51],p = 0.74,I2 = 35%), all-cause mortality (0.0...
Source: Cardiovascular Intervention and Therapeutics - Category: Cardiology Source Type: research
The association between implanted stent types and heart failure in patients with non –ST-elevation myocardial infarction (NSTEMI) remains unknown. The current study aimed to investigate whether the implantation of a newer-generation drug-eluting stent (NG-DES) compared with that of a bare-metal stent (BMS) in patients with NSTEMI who receive an undefined duration of dual antiplate let therapy (DAPT) reduces the risk of hospitalization for heart failure (HHF).
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Publication date: Available online 8 October 2020Source: Journal of Cardiology CasesAuthor(s): Masahiko Nakao, Junji Matsuda, Miho Iwai, Akira Endo, Taishi Yonetsu, Yasuhiro Otomo, Tetsuo Sasano
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
This study aimed at using siRNA transfection and lentivirus infection to regulate the expression of xist and miR-7a-5p, and to evaluate their effects on LPS-induced myocardial damage. Method: Mice cardiomyocytes (MCM) cells were divided into six groups, namely the control group, the LPS group, the LPS + lncRNA- group, the LPS + lncRNA+ group, the LPS + miRNA- group, and the LPS + miRNA+ group. Quantitative real-time PCR (qRT-PCR) was performed to assay for the RNA expressions of xist, miR-7a-5p, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), and recombinant mitochondrial transcripti...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Watching another human die will stick with anyone at any age. But when you ’re 15, it can become part of who you are and who you become. That's the story of Vita Inclinata Technologies. Company President Caleb Carr was training as a volunteer search and rescuer in Oregon when his instructor suffered a heart attack. A Blackhawk helicopter came but strong winds kept the rescue basket from penetrating the dense tree cover. His instructor died on the mountain. Carr couldn’t — and wouldn’t…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
HEART attacks can prove fatal but the event is largely preventable if you commit to a healthy lifestyle. What is less understood is the role winter may play in determining your risk.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
There is scarce evidence that the erythrocyte sedimentation rate (ESR) could efficiently improve the prediction accuracy of the Global Registry of Acute Coronary Events (GRACE) risk score in cases of ST-elevation myocardial infarction (STEMI). A cohort of 1094 STEMI patients undergoing primary percutaneous coronary intervention was retrospectively recruited. Patients were categorized based on the ESR values. Final endpoints included cardiovascular death and major adverse cardiovascular event (MACE) occurrence. The predictive value of combined models with the GRACE score and ESR was assessed by receiver operating character...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Myocardial infarction (MI) has been an important heart disease affecting human health. The aim of this study was to investigate the regulatory effect of abhydrolase domain containing 15 (ABHD15) on hypoxic cardiomyocytes.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
AbstractBackgroundData on the diagnostic and prognostic value of subtle abnormalities on myocardial perfusion imaging (MPI) are limited.Methods and resultsIn a retrospective single-center cohort of patients who underwent regadenoson SPECT-MPI, near-normal MPI was defined as normal left ventricular ejection fraction (LVEF  ≥ 50%) and a summed stress score (SSS) of 1-3 vs SSS = 0 in normal MPI. Borderline ischemia was defined as normal LVEF, SSS = 1-3, and a summed difference score (SDS) of 1 vs SDS = 0 in the absence of ischemia. Coronary angiography data within 6&n...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
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