Profiling the expression of fatty acid-binding proteins and fatty acid transporters in mouse microglia and assessing their role in docosahexaenoic acid-d5 uptake

Neuroinflammation is the biochemical and cellular response of the central nervous system (CNS) to injury and infection, and it has been reported to contribute to the pathology of some neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and motor neuron disease (MND) [1]. Neuroinflammation is mediated by the production of proinflammatory cytokines, chemokines, reactive oxygen species (ROS), and secondary messengers by resident CNS cells, such as astrocytes, peripherally derived immune cells, and microglia [1].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - May 26, 2021 Category: Biomedical Science Authors: Y.L. Low, Y. Pan, J.L. Short, J.A. Nicolazzo Source Type: research