Differences in the Mitochondrial Microsatellite Instability of Keratoacanthoma and Cutaneous Squamous Cell Carcinoma

Keratoacanthoma (KA) is a common cutaneous neoplasm characterized by rapid, abundant growth and spontaneous resolution. These lesions usually regress over 4-6 months, with an expulsion of the keratin plug and resorption of the tumoral mass, leaving an atrophic, hypopigmented scar [1]. One study reported that about 20% of the population are expected to develop skin cancer during their lifetime [2]. In humans, naturally occurring KAs are categorized as solitary or multiple [3] and KA is typically de novo, but studies have reported its association with genetic diseases, inflammatory dermatoses, congenital skin lesions and scars [4-8].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research