Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use

Conclusions
The intergenic region of CACNA2D3 and WNT5A was revealed as a novel locus for asthma exacerbations despite ICS treatment in European populations. Genes associated were related to trichostatin A, suggesting that this drug could regulate the molecular mechanisms involved in treatment response.

Source: European Respiratory Journal - May 13, 2021 Category: Respiratory Medicine Authors: Hernandez-Pacheco, N., Vijverberg, S. J., Herrera-Luis, E., Li, J., Sio, Y. Y., Granell, R., Corrales, A., Maroteau, C., Lethem, R., Perez-Garcia, J., Farzan, N., Repnik, K., Gorenjak, M., Soares, P., Karimi, L., Schieck, M., Perez-Mendez, L., Berce, V., Tags: Genetics, Asthma and allergy Original Articles: Asthma and genetics Source Type: research