Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use
Conclusions The intergenic region of CACNA2D3 and WNT5A was revealed as a novel locus for asthma exacerbations despite ICS treatment in European populations. Genes associated were related to trichostatin A, suggesting that this drug could regulate the molecular mechanisms involved in treatment response.
CONCLUSION: In this real-world cohort of specialist-treated US adults with SA, there was a substantial burden of exacerbations and associated healthcare resource utilization. Patients receiving biologics had a lower exacerbation burden.PMID:34273485 | DOI:10.1016/j.anai.2021.07.010
Conclusion: This study demonstrates that air pollution affects both asthma patients and healthy individuals. Through oxidant-antioxidant and thiol pathways, however, it adversely affects respiratory system of asthma patients, at a greater extent, than healthy individuals.PMID:34254843 | DOI:10.1080/02770903.2021.1955133
Overreliance on SABAs and underuse of inhaled corticosteroids are associated with increased risk of exacerbations and asthma-related death.Medscape Medical News
Chest. 2021 Jul;160(1):e51-e56. doi: 10.1016/j.chest.2021.02.022.ABSTRACTA 75-year-old woman was referred to the pulmonary office in January 2020 for cough and progressive worsening of shortness of breath over the years. Her medical history was significant for asthma that was diagnosed approximately 10 years earlier, when she first developed dyspnea. A pre-bronchodilator spirometry at that time showed severe airflow obstruction (Fig 1). The patient was incidentally found to have several noncalcified pulmonary nodules on a chest CT scan in 2015, which was obtained as a part of dyspnea workup. She underwent bronchoscopic eva...
We recently showed that multicomponent traditional Chinese medicine (TCM) therapy had steroid-sparing effects in moderate-to-severe eczema. We sought to evaluate TCM effects in severe eczema in a 7-year-old ma...
Publication date: July 2021Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 9, Issue 7Author(s): Katrien Eger, Lodewijk Pet, Els J.M. Weersink, Elisabeth H. Bel
Publication date: Available online 18 June 2021Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
The role for antibiotics in acute asthma has been historically overestimated . From a mechanistic point of view, multiplex PCR testing and conventional microbiological techniques show that>50–80% of events are associated with viral infections, and less than 20% associated with evidence of bacterial infection, with the remaining proportion presumed to be due to allergies and irritants . Consequently, antibiotics are not expected to work in the context of most asthma attacks and their routine use is not recommended. This stance is supported by a Cochrane review, which found inconsistent data to support antimic...
CONCLUSION: Today, although risk factors have been investigated for ABPA, it has not been revealed clearly. Both diagnostic criteria and treatment regimens have been described in research studies, mostly adults. In pediatric patients; clarification of diagnosis and treatment algorithms is necessary to prevent irreversible lung tissue damage and possible drug side effects.PMID:34174797 | DOI:10.3906/sag-2104-227