Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease

Nonalcoholic Fatty Liver Disease (NAFLD), the hepatic correlate of the metabolic syndrome, is a major risk factor for hepatobiliary cancer (HBC). Although chronic inflammation is thought to be the root cause of all these diseases, the mechanism whereby it promotes HBC in NAFLD remains poorly understood. Here we aim to evaluate the hypothesis that inflammation-related dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes HB carcinogenesis.

Source: Journal of Hepatology - May 5, 2021 Category: Gastroenterology Authors: Jeongeun Hyun, Muthana Al Abo, Rajesh Kumar Dutta, Seh Hoon Oh, Kun Xiang, Xiyou Zhou, Raquel Maeso-D íaz, Rebecca Caffrey, Arun J. Sanyal, Jennifer A. Freedman, Steven R. Patierno, Cynthia A. Moylan, Manal F. Abdelmalek, Anna Mae Diehl Source Type: research