Pyruvate production by < em > Escherichia coli < /em > using pyruvate dehydrogenase variants

This study describes an additional tool to modify central metabolism and direct metabolic flux to a product. We have shown that variants of the pyruvate dehydrogenase complex can direct metabolic flux away from cell growth to increase pyruvate production in Escherichia coli This approach could be paired with existing strategies to optimize metabolism and create industrially relevant and economically feasible processes.PMID:33863707 | DOI:10.1128/AEM.00487-21
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Source Type: research