Cancers, Vol. 13, Pages 1925: Fallopian Tube-Derived Tumor Cells Induce Testosterone Secretion from the Ovary, Increasing Epithelial Proliferation and Invasion
In this report, imaging mass spectrometry identified that testosterone is produced by the ovary when exposed to tumorigenic fallopian tube derived PTEN deficient cells. Androgen exposure increased cellular viability, proliferation, and invasion of murine cell models of healthy fallopian tube epithelium and PAX2 deficient models of the preneoplastic secretory cell outgrowths (SCOUTs). Proliferation and invasion induced by androgen was reversed by co-treatment with androgen receptor (AR) antagonist, bicalutamide. Furthermore, ablation of phosphorylated ERK reversed proliferation, but not invasion. Investigation of two hyperandrogenic rodent models of polycystic ovarian syndrome revealed that peripheral administration of androgens does not induce fallopian proliferation in vivo. These data suggest that tumorigenic lesions in the fallopian tube may induce an androgenic microenvironment proximal to the ovary, which may in turn promote proliferation of the fallopian tube epithelium and preneoplastic lesions.
Source: Cancers - Category: Cancer & Oncology Authors: Jose A. Colina Katherine E. Zink Kanella Eliadis Reza Salehi Emma S. Gargus Sarah R. Wagner Kristine J. Moss Seth Baligod Kailiang Li Brenna J. Kirkpatrick Teresa K. Woodruff Benjamin K. Tsang Laura M. Sanchez Joanna E. Burdette Tags: Article Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Chemistry | Epidemiology | Epithelial Cancer | Fallopian Tube Cancer | Ovarian Cancer | Ovaries | Serous Carcinoma