Comparison of human and rodent cell models to study myocardial lipid-induced insulin resistance

The enduring availability of sufficient chemical energy, in the form of ATP, is vital for proper cardiac function. Energy is needed not only for rhythmic contraction of the cardiomyocytes but also for ion homeostasis, and for the functioning of enzymes, proteins and organelles involved in the selection, uptake, and utilization of fuels used to produce ATP. The energy needs of the heart cannot be overestimated as, for instance, the human heart is responsible for approximately 10% of whole-body fuel consumption [1].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 12, 2021 Category: Biomedical Science Authors: Li-yen Wong, Jan F.C. Glatz, Shujin Wang, Ilvy M.E. Geraets, Sabina Vanherle, Arthur van den Wijngaard, Han Brunner, Joost J.F.P. Luiken, Miranda Nabben Tags: Original research article Source Type: research