Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study

CONCLUSIONS: Genetic predisposition to higher systemic inflammatory markers are primarily associated with somatic/neurovegetative symptoms of depression such as changes in appetite and fatigue, consistent with previous studies based on circulating levels of inflammatory markers. We extend these findings by providing evidence that associations are direct (using network analysis) and extend to genetic predisposition to immuno-metabolic markers (using PRSs). Our findings can inform selection of patients with inflammation-related symptoms into clinical trials of immune-modulating drugs for MDD.PMID:33794315 | DOI:10.1016/j.bbi.2021.03.024

Source: Brain, Behavior, and Immunity - April 1, 2021 Category: Neurology Authors: Nils Kappelmann Darina Czamara Nicolas Rost Sylvain Moser Vanessa Schmoll Lucia Trastulla Jan Stochl Susanne Lucae Elisabeth B Binder Golam M Khandaker Janine Arloth CHARGE inflammation working group Source Type: research