Metformin induces PGC‐1α expression and selectively affects hepatic PGC‐1α functions

Conclusions and ImplicationsDownregulation of PGC‐1α is not necessary for suppression of gluconeogenic genes by metformin. Importantly, metformin selectively regulates hepatic PGC‐1α‐mediated gene regulation and prevents activation of gluconeogenesis, but leaves regulation of mitochondrial genes intact. Our results thus identify selective modulation of hepatic PGC‐1α functions as a novel mechanism involved in the therapeutic action of metformin.

Source: British Journal of Pharmacology - January 16, 2014 Category: Drugs & Pharmacology Authors: Sanna‐Mari Aatsinki, Marcin Buler, Henriikka Salomäki, Markku Koulu, Petr Pavek, Jukka Hakkola Tags: Research Paper Source Type: research