Beneficial effects of tolvaptan on atrial remodeling induced by chronic intermittent hypoxia in rats

ConclusionsCIH ‐induced significant atrial remodeling in our rat model, which was attenuated by tolvaptan. These changes may be explained due to alterations in miR‐21/Spry1/ERK/MMP‐9, miR‐21/PTEN/PI3K/AKT, and NF‐κB pathways by tolvaptan.

Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Kai Zhang, Zuowang Ma, Weiding Wang, Ruimeng Liu, Yue Zhang, Meng Yuan, Guangping Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research