Short time to blood culture positivity in Enterococcus faecalis infective endocarditis

AbstractTime to blood culture positivity (TTP) is an indirect measure of bacterial concentration in blood. A short TTP has been linked to the presence of infective endocarditis (IE) and to poor prognosis inStaphylococcus aureus bacteremia. We analyze factors influencing TTP in bacteremia withEnterococcus faecalis. This retrospective observational study of medical records included adults diagnosed with monomicrobialE.faecalis bacteremia between 2015 and 2018 in the Sk åne region (Sweden). For each episode, the shortest TTP was recorded. Median TTP was compared between patients grouped based on age, sex, comorbidity, site of acquisition, and focus of infection. Using a dichotomized TTP (shorter or longer than 12 h), a multivariable logistic regression for factors associated to TTP was performed. The association between TTP and IE or mortality was evaluated. Three hundred sixty-seven episodes with monomicrobialE.faecalis bacteremia with the corresponding TTP were identified. Median TTP for the entire cohort was 11.6 (IQR 9.9 –14.1) h and a significantly shorter TTP was noted for episodes which represented IE (n = 55, 9.4 (IQR 6.4 –10.6) h). Only IE remained associated with a short TTP (≤ 12 h) in binary logistic regression analysis. Factors associated with IE were investigated and TTP was associated with IE also when adjusted for age, gender, comorbidity, and nosocomial acquisition. There was no association between TTP a nd mortality. A low TTP is associated with IE inE.f...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research