Predictors of outcome in children with disorders of mitochondrial metabolism in the pediatric intensive care unit

CONCLUSIONS: The single most predictive factor for both mortality and prolonged length of stay is the presence of mechanical ventilation. Age 1-23 months is a risk factor for mortality, and infectious reason for admittance indicates risk for prolonged length of stay.IMPACT: Presence of mechanical ventilation is the factor most strongly associated with negative outcome in patients with mitochondrial disease in pediatric intensive care. Age 1-23 months is a risk factor for mortality, and infectious reason for admittance indicates risk for prolonged length of stay PRISM3 and PIM2 are not as accurate in patients with mitochondrial disease as in a mixed patient population.PMID:33627817 | PMC:PMC7903037 | DOI:10.1038/s41390-021-01410-z

Source: Pediatric Research - February 25, 2021 Category: Pediatrics Authors: Johannes K Ehinger Michael Karlsson Fredrik Sj övall M ärta Leffler Shana E McCormack Sherri E Kubis Anna Åkesson Marni J Falk Todd J Kilbaugh Source Type: research