Idiopathic CD4 lymphocytopenia presenting as cryptococcal meningitis

Preet Mukesh Shah, Ankita Prashant Hingolikar, Shruti Tandan, Vijay Waman DhakreJournal of Global Infectious Diseases 2021 13(1):56-58A 54-year-old male presented to our center with a 3-month history of headache, giddiness, and blurring of vision. Cerebrospinal fluid examination revealed him to be having cryptococcal meningitis. He was worked up for probable causes of immunosuppression including HIV and other infections and had an autoimmune profile as well as a bone marrow examination, none of which revealed any abnormality. Lymphocyte flow cytometry revealed low counts of CD4 T lymphocytes, likely secondary to idiopathic CD4 lymphocytopenia. He was treated for cryptococcal meningitis. Due to marked immunosuppression, the disease progressed rapidly with deterioration in neurological and hemodynamic status, leading to his demise.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research