Impact of Next-Generation Sequencing Cell-free Pathogen DNA Test on Anti-Microbial Management in Adults with Hematological Malignancies and Transplant Recipients with Suspected Infections

Infections are a leading cause of morbidity and mortality in hematologic malignancies (HM) and hematopoietic stem cell transplant recipients (SCT)1 –3. It has been suggested that bacteremia occurs in 10% to 25% of patients with febrile neutropenia and can be difficult to diagnose via traditional blood cultures and fluid analysis4. Despite fungal prophylaxis, invasive fungal infections (IFI) still occur in approximately 3.5% of patients causin g considerable morbidity and mortality5,6. IFI's often require tissue biopsies and as a result are challenging to diagnose in allogeneic SCT patients or recipients of intensive chemotherapy.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Regular Manuscript (Original Research) Source Type: research