Hippocampal epigenetic and insulin-like growth factor alterations in noninvasive versus invasive mechanical ventilation in preterm lambs

CONCLUSIONS: NRS leads to distinct IGF1 mRNA variant levels and epigenetic profile in the hippocampus compared to IMV.IMPACT: Our study shows that 3 or 21 days of NRS of preterm lambs leads to distinct IGF1 mRNA variant levels and epigenetic profile in the hippocampus compared to IMV. Preterm infant studies suggest that NRS leads to better neurodevelopmental outcomes later in life versus IMV. Also, duration of IMV is directly related to hippocampal damage; however, molecular players remain unknown. NRS, as a gentler mode of respiratory management of preterm neonates, may reduce damage to the immature hippocampus through an epigenetic mechanism.PMID:33603215 | PMC:PMC7891485 | DOI:10.1038/s41390-020-01305-5

Source: Pediatric Research - February 19, 2021 Category: Pediatrics Authors: Xingrao Ke Bohan Xing Mar Janna Dahl Jeremy Alvord Robert A McKnight Robert H Lane Kurt H Albertine Source Type: research