Oxytocin-induced increase in N , N -dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms

ConclusionOur findings demonstrate an association ofN,N-dimethylglycine upregulation with the time-course change in the efficacy of oxytocin on autistic social deficits. Furthermore, the current findings support the involvement of theN-methyl-D-aspartate receptor and neural plasticity to the time-course change in oxytocin ’s efficacy.Trial registration: A multi-center, parallel-group, placebo-controlled, double-blind, confirmatory trial of intranasal oxytocin in participants with autism spectrum disorders (the date registered: 30 October 2014; UMIN Clinical Trials Registry:https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017703) (UMIN000015264).
Source: Molecular Autism - Category: Molecular Biology Source Type: research