Deleterious variants in genes regulating mammalian reproduction in Neanderthals, Denisovans and extant humans

This study provides a comprehensive overview of putatively deleterious variants in extant human populations and extinct individuals occurring in 1734 protein-coding genes controlling reproduction and provides the fundaments for future functional studies of extinct variants in human reproduction.STUDY FUNDING/COMPETING INTEREST(S)This study was supported by the Department of Biological Science and by the Office of Research and Sponsored Programs at the University of Tulsa (Faculty Research Grant and Faculty Research Summer Fellowship) to M.A. and the University of Tulsa, Tulsa Undergraduate Research Challenge (TURC) program to E.L.; no conflict of interest to declare.TRIAL REGISTRATION NUMBERN/A
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research