Microenvironment ‐Protected Exosome‐Hydrogel for Facilitating Endometrial Regeneration, Fertility Restoration, and Live Birth of Offspring

In this study, a multifunctional microenvironment‐prote cted exosome‐hydrogel is designed for facilitating endometrial regeneration and fertility restoration via in situ microinjection and endometrial regeneration. This exosome hydrogel is formulated via Ag+‐S dynamic coordination and fusion with adipose stem cell‐derived exosomes (ADSC‐exo), yielding an injectable preparation that is sufficient to mitigate infection risk while also possessing the antigenic contents and paracrine signaling activity of the ADSC source cells, enabling regeneration of the endometrial microenvironment. In vitro, this exosome‐hydrogel exerts an outstanding neovascularization‐promoting effect, increased human umbilical vein endothelial cell proliferation and tube formation for 1.87 and 2.2 folds. In vivo, microenvironment‐protected exosome‐hydrogel also r eveals to promote neovascularization and tissue regeneration while suppressing local tissue fibrosis. Importantly, regenerated endometrial tissue is more receptive to give embryos and birth to a healthy newborn. This microenvironment‐protected exosome‐hydrogel system offers a convenient, safe, a nd noninvasive approach for repairing thin endometrium and fertility restoration.

Source: Small - February 16, 2021 Category: Nanotechnology Authors: Jiaying Lin, Zhen Wang, Jialyu Huang, Shengluan Tang, Qimanguli Saiding, Qianqian Zhu, Wenguo Cui Tags: Research Article Source Type: research