Hippocampal Aromatase Knockdown Aggravates Ovariectomy-Induced Spatial Memory Impairment, A β Accumulation and Neural Plasticity Deficiency in Adult Female Mice.

In conclusion, the above results clearly demonstrated the crucial role of hippocampal E2 in the regulation of the structure and function of hippocampus besides ovarian E2, indicating that hippocampal E2 content should also be taken into consideration during estrogenic replacement.
PMID: 33559105 [PubMed - as supplied by publisher]

Source: Neurochemical Research - February 8, 2021 Category: Neuroscience Authors: Lan Z, Meng Z, Lian B, Liu M, Sun T, Sun H, Liu Z, Hu Z, Guo Q, Zhang J Tags: Neurochem Res Source Type: research