Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome

ConclusionsOur data enhance rigor and translatability as our study provides important corroboration of previous reports on epileptiform and elevated delta power. For the first time we report neurophysiological phenotypes collected via translational methodology. Furthermore, this is the first report of reduced sleep spindles, a critical marker of memory consolidation during sleep, in an AS model. Our results are useful outcomes for therapeutic testing.
Source: Molecular Autism - Category: Molecular Biology Source Type: research