Rad-GTPase contributes to heart rate via L-type calcium channel regulation
Sinoatrial node cardiomyocytes (SANcm) possess automatic, rhythmic electrical activity. SAN rate is influenced by autonomic nervous system input, including sympathetic nerve increases of heart rate (HR) via activation of β-adrenergic receptor signaling cascade (β-AR). L-type calcium channel (LTCC) activity contributes to membrane depolarization and is a central target of β-AR signaling. Recent studies revealed that the small G-protein Rad plays a central role in β-adrenergic receptor directed modulation of LTCC.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Bryana M. Levitan, Brooke M. Ahern, Ajoy Aloysius, Laura Brown, Yuan Wen, Douglas A. Andres, Jonathan Satin Source Type: research