Linking the CHRNA5 SNP to drug abuse liability: from circuitry to cellular mechanisms.

Linking the CHRNA5 SNP to drug abuse liability: from circuitry to cellular mechanisms. Neuropharmacology. 2021 Feb 01;:108480 Authors: Brynildsen JK, Blendy JA Abstract Genetics are known to be a significant risk factor for drug abuse. In human populations, the single nucleotide polymorphism (SNP) D398N in the gene CHRNA5 has been associated with addiction to nicotine, opioids, cocaine, and alcohol. In this paper, we review findings from studies in humans, rodent models, and cell lines and provide evidence that collectively suggests that the Chrna5 SNP broadly influences the response to drugs of abuse in a manner that is not substance-specific. This finding has important implications for our understanding of the role of the cholinergic system in reward and addiction vulnerability. PMID: 33539855 [PubMed - as supplied by publisher]
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research