Resolvin D1 Enhances Necroptotic Cell Clearance Through Promoting Macrophage Fatty Acid Oxidation and Oxidative Phosphorylation.

CONCLUSIONS: These results suggest that NCs derange resolution by limiting specialized proresolving mediator (eg, RvD1) synthesis and through an impairment in the efferocytic repertoire of macrophages. Moreover, these findings provide a molecular mechanism for RvD1 in directing proresolving metabolic programs in macrophages and further suggests RvD1 as a potential therapeutic strategy to limit NCs in tissues.
PMID: 33472399 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Hosseini Z, Marinello M, Decker C, Sansbury BE, Sadhu S, Gerlach BD, Bossardi Ramos R, Adam AP, Spite M, Fredman G Tags: Arterioscler Thromb Vasc Biol Source Type: research