Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia

Genes involved in the regulation of hematopoietic stem cells (HSCs) are frequently mutated or aberrantly expressed in hematologic malignancies such as acute leukemia, implying the presence of molecular machinery shared between normal HSCs and leukemic cells. Among them is BAALC (brain and acute leukemia cytoplasmic), which has been identified as a leukemia-associated gene. BAALC is highly expressed in neuroectoderm-derived cells and in CD34 positive HSCs in human [1]. From reports up to present, BAALC expression levels showed a continuum ranging [2].

Source: Experimental Hematology - January 13, 2021 Category: Hematology Authors: Hiroaki Maki, Akihide Yoshimi, Takashi Shimada, Shunya Arai, Fumio Nakanara, Ken Morita, Yasuhiko Kamikubo, Masaya Ikegawa, Mineo Kurokawa Tags: Brief Communication Source Type: research