Lipid Nanoparticles Carrying Calcium Phosphate and Citrate are Selectively Toxic to Cancer Cells

Researchers here note an approach to destructively destabilizing the metabolism of cancer cells via lipid nanoparticle delivery of calcium phosphate and citrate. The precise details of the mechanisms by which cancer cells are specifically vulnerable to this mode of delivery, while normal cells essentially reject the nanoparticles, are presently unknown. That will likely limit the further development of this approach to therapy until there is a greater understanding of how exactly it works, even given the promising initial results in mice. Researchers have developed a novel type of nanoparticle that efficiently and selectively kills cancer cells, thus opening up new therapeutic options for the treatment of tumors. Both calcium phosphate and citrate are involved in the regulation of many cellular signaling pathways. Hence, the levels of these substances present in the cytoplasm are tightly controlled, in order to avoid disruption of these pathways. Crucially, the nanoparticles described in the new study are able to bypass these regulatory controls. Researchers repared amorphous and porous nanoparticles consisting of calcium phosphate and citrate, which are encapsulated in a lipid layer. The encapsulation ensures that these particles are readily taken up by cells without triggering countermeasures. Once inside the cell, the lipid layer is efficiently broken down, and large amounts of calcium and citrate are deposited in the cytoplasm. Experiments on cultured cell...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs