Targeted PET Imaging of Chemokine Receptor 2-Positive Monocytes and Macrophages in the Injured Heart

Conclusion: This work establishes the utility of 64Cu-DOTA-ECL1i to image CCR2+ monocytes and macrophages in mouse models and provides the requisite preclinical information to translate the targeted clinical-grade CCR2 imaging probe for clinical investigation of heart diseases.

Source: Journal of Nuclear Medicine - December 17, 2020 Category: Nuclear Medicine Authors: Heo, G. S., Bajpai, G., Li, W., Luehmann, H. P., Sultan, D. H., Dun, H., Leuschner, F., Brody, S. L., Gropler, R. J., Kreisel, D., Lavine, K. J., Liu, Y. Tags: Basic Source Type: research