Nephrotic Range Proteinuria associated with Focal Segmental Glomerulosclerosis Reversed with Pioglitazone Therapy in a Patient with Dunnigan Type  Lipodystrophy

Familial partial lipodystrophy(FPLD) is a rare disorder associated with severe insulin resistance, hypertriglyceridemia, low serum HDL cholesterol and proteinuric renal disease. Although proteinuric renal disease is not common among in patients with partial lipodystrophy, we report a patient with Dunnigan type FPLD complicated by nephrotic syndrome which resolved following treatment with the PPAR γ agonist pioglitazone, CPAP, diet, and exercise.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Tags: Brief Report Source Type: research