In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces

ConclusionsOur data support a paradigm in which Xenopus embryonic ventriculogenesis and rostral brain development are critically dependent on ependymal cilia-driven CSF flow currents that are generated independently of cardiac pulsatile forces. Our work suggests that the Xenopus ventricular system forms a complex cilia-driven CSF flow network which regulates neural cell organization. This work will redirect efforts to understand the molecular regulators of embryonic CSF flow by focusing attention on motile cilia rather than other forces relevant only to the adult.

http://link.springer.com/10.1186/s12987-020-00234-z

Source: Fluids and Barriers of the CNS - December 11, 2020 Category: Neuroscience Source Type: research