Autophagic Dysfunction in Dementia: Scope for Development of Potential Remedies.

Autophagic Dysfunction in Dementia: Scope for Development of Potential Remedies. CNS Neurol Disord Drug Targets. 2020 Dec 08;: Authors: Kumar B, Pandey M, Mishra AK, Sharma A, Fayaz F, Pottoo FH Abstract Dementia is a diverse category of a chronic and progressive disorder, which is commonly associated with loss of memory, difficulty in judgment, impaired language, cognitive impairment, and various other symptoms that affects a person's daily routine life and social life. Dementia affects about 50 million people around the globe. Dementia exists in varied forms and is associated with various neurodegenerative disorders. Alzheimer's disease dementia is the most common form which accords for about 60% cases. Abnormal agglomeration of proteins in the brain has been linked to the pathogenesis of dementia. Autophagy is a necessary protein clearance mechanism, which is dependent on lysosomes. It is a basic physiological process that performs the crucial function of maintaining protein homeostasis within the cells. The autophagic dysfunction in dementia further complicates the disease by hampering the degradation and removal of abnormal pathogenic proteins. In order to understand autophagic dysfunction, it is essential to know the genetics of autophagy as well as the mutations which cause autophagic dysfunction. This understanding at the genetic level helps to define the relationship between dementia and autophagic dysfunction for developing...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research