Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function

ConclusionsTherefore, our data suggest that by using the status of the p53 protein as a selection criterion, the ERR α/p53 transcriptional axis can be exploited as a metabolic vulnerability.
Source: Cancer and Metabolism - Category: Cancer & Oncology Source Type: research