Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.

CONCLUSIONS: Both ROCK1 and ROCK2 are required for HCC cell division and growth. Targeting ROCK1 or ROCK2 rather than both can serve as a potential approach for HCC treatment and may reduce the side effects.
PMID: 33278350 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - December 2, 2020 Category: Drugs & Pharmacology Authors: Wu H, Chen Y, Li B, Li C, Guo J, You J, Hu X, Kuang D, Qi S, Liu P, Li L, Xu C Tags: Biochem Pharmacol Source Type: research