The nutrient sensing pathways FoxO1/3 and mTOR in the heart are coordinately regulated by central leptin through PPAR β/δ. Implications in cardiac remodeling

Cardiovascular disease in obese individuals with type 2 diabetes is often associated with hyperleptinemia and leptin resistance, while other studies support that leptin has cardioprotective effects. Besides, the role of leptin in regulating cardiac atrophy or hypertrophy remains to be clearly defined. In fact, in rats with normal leptin sensitivity, the molecular underpinnings of the effects of central leptin regulating cardiac structural pathways remain poorly understood.

Source: Metabolism - Clinical and Experimental - November 26, 2020 Category: Biomedical Science Authors: Blanca Rubio, Cristina Mora, Cristina Pintado, Lorena Mazuecos, Alejandro Fern ández, Virginia López, Antonio Andrés, Nilda Gallardo Source Type: research