Delayed Pituitary Adenylate Cyclase-Activating Polypeptide Delivery After Brain Stroke Improves Functional Recovery by Inducing M2 Microglia/Macrophage Polarization [Basic Sciences]

Conclusions— Our results demonstrated that immunomodulatory strategies capable of redirecting the microglial response toward a neuroprotective M2 phenotype in the late phase of brain ischemia could represent attractive options for stroke treatment in a new and unexploited therapeutical window.

http://stroke.ahajournals.org/cgi/content/short/46/2/520?rss=1

Source: Stroke - January 26, 2015 Category: Neurology Authors: Brifault, C., Gras, M., Liot, D., May, V., Vaudry, D., Wurtz, O. Tags: Embolic stroke Basic Sciences Source Type: research