Purinergic receptor antagonism: A viable strategy for the management of autonomic dysreflexia?

Purinergic receptor antagonism: A viable strategy for the management of autonomic dysreflexia? Auton Neurosci. 2020 Nov 16;230:102741 Authors: Minic Z, O'Leary DS, Reynolds CA Abstract The purinergic receptor ligand, ATP, may participate in reflex induced vasoconstriction through sympathetic efferent and sensory afferent mechanisms. However, the role of the purinergic system in contributing to autonomic dysreflexia following spinal cord injury is unclear. The present study investigates the involvement of P2X receptors in contributing to pressor responses during autonomic dysreflexia. Twenty rats were subjected to spinal cord injury and 24 h later hemodynamic responses to colorectal distension were recorded. Animals were randomized to receive intravenous administration of the P2X receptor antagonist, NF023, or vehicle control. The data indicate that NF023 attenuates pressor responses to colorectal distension. PMID: 33220530 [PubMed - as supplied by publisher]
Source: Autonomic Neuroscience - Category: Neuroscience Authors: Tags: Auton Neurosci Source Type: research