Micro-RNA (miRNA): A biomarker to identify novel compounds in drug discovery and delivery for cancer therapy.
Micro-RNA (miRNA): A biomarker to identify novel compounds in drug discovery and delivery for cancer therapy.
Curr Drug Discov Technol. 2020 Nov 16;:
Authors: Paramasivam G
Abstract
Micro-RNAs (miRNA) are short non-coding sequences involved in the biological regulatory process. The miRNA shows a unique expression in diseases resulting in the pathogenesis. Identifying the novel compounds are interesting during this process. The miRNA is a biomarker that helps to find the early stage of cancer disease through pathogenesis. Azobenzene and pyrazole are the novel compounds having a cytotoxic effect on cancer cells. These novel compounds are molecular probe used in breast cancer therapy. The viral-based systems have few limitations such as toxicity and immunogenicity. So, the non-viral based lipoplex and polyplex systems are attractive due to no size limitations for the transfection of micro RNAs. The conventional drug delivery systems are having a large size and low drug efficacy at the target site. The nanoparticles prepared by nanoprecipitation methods are attractive in cancer therapy. Thus, the miRNA acts as a powerful tool and is used to identify the drug target in cancer therapy.
PMID: 33208078 [PubMed - as supplied by publisher]
Source: Current Drug Discovery Technologies - Category: Drugs & Pharmacology Authors: Paramasivam G Tags: Curr Drug Discov Technol Source Type: research
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