Nuclear receptor TLX may be through regulating the SIRT1/NF- κB pathway to ameliorate cognitive impairment in chronic cerebral hypoperfusion.

CONCLUSIONS: The present findings suggested that TLX exerted protective effects against cognitive deficits induced by CCH. The possible mechanisms of TLX may be through regulating the SIRT1/NF-κB pathway, promoting hippocampal neurogenesis and inhibiting the neuroinflammatory response. PMID: 33197535 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33197535?dopt=Abstract

Source: Brain Research Bulletin - November 13, 2020 Category: Neurology Authors: Qu C, Qu C, Xu L, Shen J, Lv D, Li Y, Song H, Li T, Zheng J, Zhang J Tags: Brain Res Bull Source Type: research