Disrupted prefrontal neuronal oscillations and morphology induced by sleep deprivation in young APP/PS1 transgenic AD mice.

This study suggests that failure to acquire adequate sleep could trigger an early electrophysiological, molecular, and morphological alteration in the PFC of AD mice. Therapeutic interventions that manipulate sleep by targeting these pathways may be a promising approach toward delaying the progression of this incurable disease.
PMID: 33186630 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - November 10, 2020 Category: Neurology Authors: Tabassum S, Misrani A, Tabassum S, Ahmed A, Yang L, Long C Tags: Brain Res Bull Source Type: research