Monensin-Induced Increase in Intracellular Na < sup > + < /sup > Induces Changes in Na < sup > + < /sup > and Ca < sup > 2+ < /sup > Currents and Regulates Na < sup > + < /sup > -K < sup > + < /sup > and Na < sup > + < /sup > -Ca < sup > 2+ < /sup > Transport in Cardiomyocytes

Conclusion: These results suggest that the monensin-induced shortened APD and reduced amplitude of the plateau phase are primarily due to the decrease in the ICa, the activation of the reverse mode of INa-Ca, and the increased INa-K, and second due to the decreased INa. The IK and the IK1 may not be associated with the abovementioned changes induced by monensin. The elevation of [Na]i can exert multiple influences on electrophysiological phenomena in cardiac myocytes.Pharmacology
Source: Pharmacology - Category: Drugs & Pharmacology Source Type: research