Exploring the effectiveness of incorporating carbon nanotubes into bioengineered scaffolds to improve cardiomyocyte function.

Exploring the effectiveness of incorporating carbon nanotubes into bioengineered scaffolds to improve cardiomyocyte function.
Expert Rev Clin Pharmacol. 2020 Oct 26;:
Authors: Ghai P, Mayerhofer T, Jha RK
Abstract
INTRODUCTION: Carbon nanotubes are effective in improving scaffolds to enhance cardiomyocyte function and hold great promise in the field of cardiac tissue engineering.
AREAS COVERED: A PubMed and Google Scholar search was performed to find relevant literature. 18 total studies were used as primary literature. The literature revealed that the incorporation of carbon nanotube into biocompatible scaffolds that mimic myocardial extracellular matrix, enhanced the ability to promote cell functions by improving physical profiles of scaffolds. Several studies showed improved scaffold conductance, mechanical strength, improvements in cell properties such as viability, and beating behaviour of cells grown on carbon nanotube incorporated scaffolds. Carbon nanotubes present a unique opportunity in the world of tissue engineering through reparation and regeneration of the myocardium, an otherwise irreparable tissue.
EXPERT OPINION: The high burden of cardiovascular disease has prompted research into cardiac tissue engineering applications. Carbon nanotube incorporation into extracellular matrix-mimicking-scaffolds has shown to improve cardiomyocyte conductivity, viability, mechanical strength, beating behaviour, and hav...

Source: Expert Review of Clinical Pharmacology - October 27, 2020 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research