A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways

Cognitive impairment (CI) is a frequent complication affecting people with multiple sclerosis (MS). The causes of CI in MS are not fully understood. Besides MRI measures, few other biomarkers exist to help us predict the development of CI and understand its biology. MicroRNAs (miRs) are relatively stable, non-coding RNA molecules about 22 nucleotides in length that can serve as biomarkers and possible therapeutic targets in several autoimmune and neurodegenerative diseases, including the dementias.

https://www.jns-journal.com/article/S0022-510X(20)30538-4/fulltext?rss=yes

Source: Journal of the Neurological Sciences - October 22, 2020 Category: Neurology Authors: Aditi Vian Varma-Doyle, Walter J. Lukiw, Yuhai Zhao, Jesus Lovera, Deidre Devier Tags: Review Article Source Type: research