The Roles of γδ T Cells in Hematopoietic Stem Cell Transplantation.

The Roles of γδ T Cells in Hematopoietic Stem Cell Transplantation.
Cell Transplant. 2020 Jan-Dec;29:963689720966980
Authors: Ye W, Kong X, Zhang W, Weng Z, Wu X
Abstract
The αβ T-cell-depleted hematopoietic stem cell transplantation (HSCT) leads to lower relapse and better outcome, and may correlate strongly with expansion of donor-derived γδ T cells. γδ T cells play an important role in immune reconstitution and can exert a graft-versus-leukemia effect after HSCT. This review showed the recent literature on immune functions of γδ T cells after HSCT. The discrepancies between studies of γδ T cells in graft-versus-host disease may cause by its heterogeneous and various distinct subsets. And reconstitution of γδ T cells may play a potential immunoregulatory role in the infections after HSCT.
PMID: 33073597 [PubMed - in process]

Source: Cell Transplantation - January 1, 2020 Category: Cytology Authors: Ye W, Kong X, Zhang W, Weng Z, Wu X Tags: Cell Transplant Source Type: research