Protective Effects of Cydonia oblonga Mill. ...

Quince (Cydonia oblonga Mill.) is one of the medicinal plants with a broad range of pharmacological activities. The present study was conducted to evaluate the protective effects of aqueous extract of Cydonia oblonga Mill. fruit (ACOF) against carbon tetrachloride (CCl4)-induced liver damage in rats. The serum biomarkers of hepatotoxicity, hepatic oxidative stress markers, liver morphology and histology, and adenosine triphosphate (ATP) contents of liver mitochondria were examined to assess the hepatoprotective effects. Hepatotoxicity was induced by CCl4 and test animals were administered the extract orally at three different doses for 5 consecutive days. The extract showed hepatoprotective activity as evidenced by significant decreases in serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and bilirubin in the intoxicated rats. In addition, the antioxidant capacity of the extract resulted in the reduction of lipid peroxidation along with the restoration of reduced glutathione (GSH) in the liver. Moreover, ACOF markedly restored the bioenergetic depletion and ATP production collapse in the intoxicated rats, which were evaluated by a validated high performance liquid chromatography (HPLC) method. Finally, histopathological staining of the rat livers confirmed the hepatoprotective activity of ACOF. It can be conclude that the role of ACOF to improve liver function on CCl4-hepatoxicity could be attributed, at l...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research