Identification and in vivo characterization of a brain-penetrating nanobody

ConclusionThis method led to the discovery of an anti-transferrin receptor nanobody that can reach the brain via receptor-mediated transcytosis after peripheral administration. This method could be used to assess novel proteins for brain-penetrating capabilities using a target-engaging readout.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research