Anger recall mental stress decreases 123 I-metaiodobenzylguanidine ( 123 I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy

ConclusionMental stress decreased the123I-mIBG HMR, increased mismatch between sympathetic activity and myocardial perfusion, and increased the heterogeneity of123I-mIBG uptake in ICM patients, while there was no significant change in myocardial defect size or the heterogeneity of99mTc-Tetrofosmin perfusion. The changes observed in this proof-of-concept study may provide valuable information about the trigger –substrate interaction and the potential vulnerability for ventricular arrhythmias.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research

Related Links:

Rationale: Stellate Ganglion Block (SGB) provides a blockade of sympathetic signals from the sympathetic chain and appears to be a promising method of controlling refractory ventricular arrhythmias, but there are scanty data in the literature. Patient concerns: Herein, we describe a 59-year-old male patient with a history of non-ischemic cardiomyopathy and suffering from frequent VT episodes, who received ICD implantation and regular amiodarone medication control. Diagnoses: Monomorphic VT refractory to standard medication control and focal extensive catheter ablation. Interventions: Left Stellate Ganglion Block...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Heightened sympathetic nerve activity is associated with occurrence of ventricular arrhythmia (VA).
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
AbstractPurpose of ReviewTo review the contributions of radionuclide imaging to understanding the manifestations and pathophysiology of chronic Chagas cardiomyopathy (CCC).Recent FindingsExperimental studies using high-resolution SPECT myocardial perfusion imaging (MPI) show that myocardial perfusion derangement that corresponds to dysfunctional, viable myocardium is closely linked to inflammation and precedes LV regional systolic dysfunction. Clinical studies show that microvascular ischemia is strictly related to the areas of cardiac sympathetic denervation, assessed by123I-MIBG imaging, which correlates with severe vent...
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research
We report the clinical follow-up of two patients with non-obstructive HCM implanted with a cardioverter defibrillator (ICD) allowing for continuous analysis of heart rate (HR), heart rate variability (HRV) and cardiac arrhythmia throughout the entire course of pregnancy. Both patients experienced increased HR and decreased HRV from the early stages of pregnancy, which persisted until delivery. Premature ventricular contractions (PVCs) and runs of non-sustained ventricular tachycardia (NSVT) reached a peak in the second and third trimesters, concurrent with sympathetic hyperactivity. In one patient with baseline NYHA class ...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Conclusions: Inhibition of reactive oxygen species or ox-CaMKII protects against proarrhythmic intracellular Ca2+ handling and prevents ventricular arrhythmia in a mouse model of Duchenne muscular dystrophy.
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Arrhythmias, Animal Models of Human Disease, Cell Signaling/Signal Transduction, Oxidant Stress, Cardiomyopathy Original Articles Source Type: research
Conclusions: Early experience suggests that SGB is associated with an acute reduction in the VA burden and offers potential promise for a broader use in high‐risk populations. Randomized controlled studies are needed to confirm safety and efficacy of this therapy.This article is protected by copyright. All rights reserved
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: The findings suggest that biologically plausible genetic factors may alter susceptibility to PM10-associated QT prolongation in populations protected by the U.S. Environmental Protection Agency’s National Ambient Air Quality Standards. Independent replication and functional characterization are necessary to validate our findings. https://doi.org/10.1289/EHP347 Received: 11 April 2016 Revised: 07 September 2016 Accepted: 19 September 2016 Published: 08 June 2017 Address correspondence to R. Gondalia, Department of Epidemiology, University of North Carolina, 137 E. Franklin St., Chapel Hill, NC 27514...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Abstract Background To investigate the correlation between the extent of myocardial sympathetic denervation and fibrosis and the presence of degrees of severity of ventricular arrhythmias in chronic Chagas cardiomyopathy (CCC). Methods Forty-three CCC patients with left ventricular ejection fraction (LVEF) ≥ 35% were divided into three groups: SVT group—presenting Sustained Ventricular Tachycardia (SVT) (n = 15), NSVT group—exhibiting episodes of non-SVT (NSVT) on 24-h Holter monitoring (n = 11), and Control group&mdash...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
We thank Dr. Madias 1 for his interest in and comments concerning our report, which describes the incidence, characteristics, risk factors, and outcomes of Takotsubo cardiomyopathy with and without ventricular arrhythmia 2. In Takotsubo cardiomyopathy, albeit several physiological hypotheses have been suggested, a hyperadrenergic mechanism, excessive sympathetic responsiveness associated with a reduced parasympathetic modulation of heart rate is more commonly evocated 3,4. Several authors have suggested that diabetes mellitus (DM), responsible of autonomic nervous system neuropathy and adrenal cathecholamine hyposecretion,...
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
We thank Dr. Madias1 for his interest in and comments concerning our report, which describes the incidence, characteristics, risk factors, and outcomes of Takotsubo cardiomyopathy with and without ventricular arrhythmia.2 In Takotsubo cardiomyopathy, albeit several physiological hypotheses have been suggested, a hyperadrenergic mechanism, excessive sympathetic responsiveness associated with a reduced parasympathetic modulation of heart rate is more commonly evocated.3,4 Several investigators have suggested that diabetes mellitus (DM), responsible of autonomic nervous system neuropathy and adrenal cathecholamine hyposecreti...
Source: The American Journal of Cardiology - Category: Cardiology Authors: Tags: Readers' Comments Source Type: research
More News: Arrhythmia | Cardiology | Cardiomyopathy | Heart | Men | Nuclear Medicine | Perfusion | Psychology | Reflex Sympathetic Dystrophy | SPECT | Study | Ventricular Arrhythmia | Yale