Anger recall mental stress decreases 123 I-metaiodobenzylguanidine ( 123 I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy

ConclusionMental stress decreased the123I-mIBG HMR, increased mismatch between sympathetic activity and myocardial perfusion, and increased the heterogeneity of123I-mIBG uptake in ICM patients, while there was no significant change in myocardial defect size or the heterogeneity of99mTc-Tetrofosmin perfusion. The changes observed in this proof-of-concept study may provide valuable information about the trigger –substrate interaction and the potential vulnerability for ventricular arrhythmias.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research