Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary

AbstractBACKGROUNDPerfluoroalkyl and polyfluoroalkyl substances (PFAS) are found widespread in drinking water, foods, food packaging materials and other consumer products. Several PFAS have been identified as endocrine-disrupting chemicals based on their ability to interfere with normal reproductive function and hormonal signalling. Experimental models and epidemiologic studies suggest that PFAS exposures target the ovary and represent major risks for women ’s health.OBJECTIVE AND RATIONALEThis review summarises human population and toxicological studies on the association between PFAS exposure and ovarian function.SEARCH METHODSA comprehensive review was performed by searching PubMed. Search terms included an extensive list of PFAS and health terms ranging from general keywords (e.g. ovarian, reproductive, follicle, oocyte) to specific keywords (including menarche, menstrual cycle, menopause, primary ovarian insufficiency/premature ovarian failure, steroid hormones), based on the authors ’ knowledge of the topic and key terms.OUTCOMESClinical evidence demonstrates the presence of PFAS in follicular fluid and their ability to pass through the blood –follicle barrier. Although some studies found no evidence associating PFAS exposure with disruption in ovarian function, numerous epidemiologic studies, mostly with cross-sectional study designs, have identified associations of higher PFAS exposure with later menarche, irregular menstrual cycles, longer cycle length, earlier...
Source: Human Reproduction Update - Category: OBGYN Source Type: research