The effect of intermittent hypoxia and fecal microbiota of OSAS on genes associated with colorectal cancer

ConclusionsOur study demonstrated that IH and gut microbiota of patients with OSAS activated HIF-1 α expression and STAT3 pathway in IMCE cells, with no influence on β-catenin pathway, which suggested that IH, STAT3 pathway, chronic inflammation, and intestinal microbiota dysbiosis may be involved in CRC carcinogenesis correlated with OSAS These findings must be interpreted cautiously and furth er research is necessary to clarify the causative steps in CRC development.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research