Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.

In conclusion, this study suggested macrophages pyroptosis are involved in AAA and inhibition or knockout of β5i decreased macrophage pyroptosis via IκB/NFκB pathway.
PMID: 33019975 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - October 1, 2020 Category: Biochemistry Authors: Zhang X, Li F, Wang W, Ji L, Sun B, Xiao X, Wang X, Chen Y, Liu B, Ye W, Tian C, Wang H, Zheng Y Tags: Biochem Biophys Res Commun Source Type: research